Grandmother Karen Paton, 48, also sent a gift to the McCanns – a French crystal rosary cross – as a touching gesture that they are in her thoughts.
Karen, of Birley Street, Kirkham, posted the gift and a card to the McCanns' Leicestershire home.
She said Madeleine "had touched our hearts" and that she and her daughter Heather Paton, 21, could not imagine what they were going through.
Karen, a cleaner at Kirkham Police Station, said: "I've got a granddaughter the same age and I just think they are going through hell."
She added: "I've been wanting to write to them for a bit but not known what to put. But I thought I would send something with the anniversary coming up."
Karen said her granddaughter Holly, aged three-and-a-half, was "very much like Madeleine".
Madeleine went missing from her hotel room at Pria Da Luz, the Algarve, Portugal, on May 3.
Karen said: "She's such a lovely little girl. We have seen so much of her, it has got to me definitely."
Karen has had to come to terms with her own tragedy - the loss of her mother who died following an accident on the A584 at Freckleton five years ago this September.
She is planning to see spiritualist Gordon Smith in the hope of making contact with her mother.