Mick McCarthy’s side will do so with Jordan Thorniley back in contention after the defender missed the derby defeat to Preston through illness.
Elsewhere, fans have been vocal in their wish to see changes, especially in the attacking part of the pitch.
Charlie Patino, Ian Poveda and Josh Bowler all made an impact off the bench last week and could come into the starting XI as a result.
With that in mind, here’s how we think the Seasiders could line up in their must-win game...
1. Reaction required
The Seasiders must show a reaction to last week's derby debacle Photo: CameraSport - Alex Dodd
2. GK - Chris Maxwell
While there have been calls for Dan Grimshaw to return, I'd be surprised if McCarthy dispenses of Maxwell's experience. Photo: CameraSport - Dave Howarth
3. RB - Andy Lyons
If the Seasiders return to a flat back four, it's a toss up between Lyons and Jordan Gabriel for the right-back spot. Photo: CameraSport - Dave Howarth
4. CB - Curtis Nelson
He shouldn't need any added motivation, but Nelson will be fired up to face his former side who he left in January. Photo: CameraSport - Rich Linley
5. CB - Jordan Thorniley
Assuming he's fully recovered from his sickness bug, Thorniley should slot straight back into the backline. Photo: CameraSport - Dave Howarth
6. LB - James Husband
If Blackpool are going to get out of this mess, they're going to need characters of Hubby's mould. Photo: CameraSport - Alex Dodd