Seven players are likely to miss out, but crucially Jerry Yates and Gary Madine could be fit enough to feature.
Lewis Fiorini, meanwhile, comes back into contention after featuring for the development squad in midweek.
With that in mind, here’s how we think the Seasiders might line up against Vincent Kompany’s men...
1. Decisions, decisions
Mick McCarthy will be mulling over his options ahead of Saturday's game Photo: CameraSport - Andrew Kearns
2. GK - Chris Maxwell
Given who Blackpool are facing, Maxwell's likely to be kept busy so fingers crossed he's on top form. Photo: CameraSport - Andrew Kearns
3. RB - Andy Lyons
Lyons will battle it out with Jordan Gabriel for the right-back spot. Photo: CameraSport - Andrew Kearns
4. CB - Curtis Nelson
Nelson will be out to atone for his error that led to Reading's penalty last week. Photo: CameraSport - Dave Howarth
5. CB - Jordan Thorniley
Unless Callum Connolly returns to the back four, Thorniley is likely to remain at centre back. Photo: CameraSport - Ian Cook
6. LB - James Husband
Hubby will be keen to produce an improved display after a surprisingly below-par performance last time out. Photo: CameraSport - Andrew Kearns